Cholangiocarcinoma and sclerosing cholangitis: clinical characteristics and effect on survival after liver transplantation.
نویسندگان
چکیده
ORTHOTOPIC liver transplantation (OLTx) has emerged during. the last decade to be the most effective therapy for patients with advanced primary sclerosing cholangitis (PSC).1-3 The potential risk of developing cholangiocarcinoma (CCA) in these patients triggered the current study to define the clinical characteristics of patients with concomitant CCA and its effect on patient survival after transplantation.
منابع مشابه
Predicting cholangiocarcinoma in patients with primary sclerosing cholangitis before transplantation.
Patients with primary sclerosing cholangitis are at an increased risk of developing cholangiocarcinoma, which is difficult to diagnose because the biliary tree is already distorted. Eleven patients with primary sclerosing cholangitis who underwent orthotopic liver transplantation at this hospital were evaluated. Four patients had coincidental histologically proved cholangiocarcinoma. Patients w...
متن کاملAssociation between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis.
INTRODUCTION Primary sclerosing cholangitis (PSC) is an idiopathic hepatobiliary disorder associated with an increased risk for cholangiocarcinoma (CCA) and a median survival time of 12 years. Reliable predictors of CCA and other major adverse events in PSC are currently lacking. Recently, serum IgE was found to be associated with CCA in a Japanese cohort of PSC patients. Our aim in this study ...
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OBJECTIVES Patients who have a liver transplant for primary sclerosing cholangitis may develop recurrent disease and biliary complications, organ loss necessitating revision liver transplant, or death. We evaluated long-term outcomes in patients who had liver transplant for primary sclerosing cholangitis. MATERIALS AND METHODS In 71 patients who had a liver transplant for end-stage liver dise...
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BACKGROUND Candidiasis is commonly observed in patients with primary sclerosing cholangitis (PSC), but the clinical risk factors associated with its presence have not been fully investigated. In this study, we aimed to analyse the incidence, risk factors, and transplantation-free survival in primary sclerosing cholangitis (PSC) patients with persistent biliary candidiasis. METHODS We retrospe...
متن کاملLiver transplantation for cholangiocarcinoma.
Liver transplantation following high dose neoadjuvant radiotherapy with chemosensitization achieves excellent results for patients with early stage, unresectable hilar cholangiocarcinoma or cholangiocarcinoma arising in the setting of primary sclerosing cholangitis.
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 25 1 Pt 2 شماره
صفحات -
تاریخ انتشار 1993